Titans vs Colts Week 5 Prediction, Odds & Picks: Henrymania Runs Wild

The NFL Week 5 lineup has its fair share of rivalry games, including Sunday’s AFC South collision between the Tennessee Titans and Indianapolis Colts at 1 p.m. ET.

Titans week. pic.twitter.com/zU28r27LkJ

— Indianapolis Colts (@Colts) October 4, 2023

The Titans head back to the road looking to build more momentum after notching a 27-3 win over the Cincinnati Bengals. Meanwhile, the Colts couldn’t pull off the comeback win in Week 4, losing 29-23 to the LA Rams in overtime.

Can Tennessee prove that its latest victory wasn’t a fluke? Or will Indianapolis find a way to stand tall?

Read on for Betting News’ full Titans vs. Colts betting preview, including the latest game odds to my best bets and predictions for the showdown.

Titans vs Colts — NFL Week 5

TEN vs IND Game Information

• Matchup: Tennessee Titans (2-2, 0-2 Away) vs. Indianapolis Colts (2-2, 0-2 Home)
• Venue & Location: Lucas Oil Stadium (Indianapolis, IN)
• Date: Sunday, Oct. 8, 2023
• Game Time: 1 p.m. Eastern Time
• Titans vs. Colts Week 5 TV Channel: CBS

Titans vs Colts Odds

NFL game odds courtesy of Bovada as of Saturday, Oct. 7 at 7:24 p.m. ET. Odds from other sportsbooks may also be mentioned in this article.

Spread

• Tennessee Titans -2.5 (-110)
• Indianapolis Colts +2.5 (-110)

Over/Under

• Over 43 Points (-115)
• Under 43 Points (-105)

Moneyline

• Tennessee Titans -135
• Indianapolis Colts +115

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Titans vs Colts Betting Trends

• Tennessee is 5-0 straight up in its last five games against Indianapolis.
• Indianapolis is 16-4 straight up in its last 20 Week 5 matchups.
• Tennessee is 4-1 ATS In its last five road games against Indianapolis.
• Indianapolis is 0-5 ATS in its last five home games.
• The total has hit the under in five of Tennessee’s last six AFC South matchups.
• The total has hit the Over in five of Indianapolis’ last seven AFC matchups.

Titans vs Colts Week 5 Preview

The Colts haven’t had much luck when it comes to this AFC South rivalry as of late. They’ve dropped five consecutive games to the Titans, losing by an average margin of 9.4 points.

If Indianapolis is to win, the first thing it must do is slow down Tennessee’s run game. After all, the visitor’s offense runs through RB Derrick Henry.

Unfortunately, the Colts haven’t done that great of a job defending on the ground. Inconsistent play from the defensive line has seen them allow 126.8 rushing yards per game (10th-most) as well as four rushing TDs to running backs — tied for the sixth-most in the NFL.

It’s also worth noting that Henry consistently terrorizes the Colts. The three-time Pro-Bowler has racked up 853 rushing yards and five TDs in his last seven encounters with Indianapolis, finishing with no fewer than 103 yards in all but one of those games.

The Titans also have momentum stemming from a strong defensive performance in last week’s win over the Bengals.

Tennessee held Cincinnati to just 211 total yards, as well as an average of 4.1 yards per play. The Bengals also converted on just 2-of-9 third downs (22.2%) and failed to score on their only trip to the red zone.

Given that the Bengals have more offensive talent than the Colts, it wouldn’t be shocking if the home team struggles to get the ball rolling early on.

Even as solid as Indianapolis QB Anthony Richardson has been, he still has a lot to learn — highlighted by last week’s 44.0% completion rate. He’s also been sacked six times in three starts and now faces the Titans, who are up to 13 sacks this season (T-7th).

If Richardson can’t consistently make his passes early on, the Colts could be playing from behind again this weekend.

Titans vs Colts Prediction — Week 5

In a game that could go either way, I see the Titans standing tall at the final whistle. Not only are the Colts struggling to beat their divisional rival, but the fact that they were down 20-0 at halftime last week raises some serious concerns.

It’ll be a fun back-and-forth affair, but look for the Titans’ run game to give them the edge.

Prediction: Titans 20, Colts 17

Bet: Under 43 Points (-105 on Bovada)

Titans vs Colts Player Prop — Week 5

When it comes to a Titans vs. Colts player prop, it’s an absolute no-brainer to take Derrick Henry to finish with over 75.5 rushing yards.

For starters, the former Alabama product has hit the Over on this prop twice in his last three games, which includes last week’s 122-yard performance. Secondly, he’s finished with 76-plus rushing yards in 10 of his last 12 games against the Colts, averaging 107.0 yards during that span.

With Indy’s run defense looking suspect at best, hitting the Over won’t be an issue for Henry.

Bet: Derrick Henry Over 75.5 Rushing Yards (-115 on Bovada)

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Tennessee vs Indianapolis Week 5 FAQ

When is Titans vs Colts?

• The Titans and Colts will collide on Sunday, Oct. 8, 2023.

Where is Titans vs Colts?

• The Titans and Colts will play each other at Lucas Oil Stadium in Indianapolis, Indiana.

What time does Titans vs Colts start?

• Kickoff for the upcoming TEN vs. IND matchup is slated for 1 p.m. ET.

How can I watch Titans vs Colts?

• Tennessee and Indianapolis fans can tune in to CBS for Sunday’s matchup.

How can I bet on Titans vs Colts?

• All of the top online sports betting sites will have NFL odds, but here are some of the sites we recommend most for football enthusiasts.