San Francisco 49ers vs Buffalo Bills: NFL Predictions, Odds & Best Bets (12/1)

The Buffalo Bills are hosting the San Francisco 49ers for this week’s edition of Sunday Night Football, and it should be an interesting one to say the least. The city is expecting some heavy snowfall between now and kick off, and things could even spicier on the field than we expect!

The Bills look rock solid. They are 9-2 this season and a perfect 5-0 at Highmark Stadium. Buffalo has scored 30+ points in five straight games, and they are only missing a couple key players which is much different than the San Francisco sideline. The Bills are without TE Dalton Kincaid, and will see game time decisions from WR Keon Coleman and LB Matt Milano who is coming off the IR. Regardless, Josh Allen has proven he can win with whomever, and they face a 49ers team that needs to turn the ship around.

San Francisco finds themselves at the bottom of the NFC West in what will be a thrilling divisional race. They’ve now lost two straight games and 3 of their L5. They’ve put up just 27 points over the last two weeks, and they will certainly need 20+ to keep up with Buffalo in my eyes. With Brock Purdy likely back on the field, this helps San Francisco’s chances, but they still have a very tough task in New York.

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San Francisco 49ers vs Buffalo Bills: Snowy Sunday Night Football

Will the Bills take down the 49ers at home this Sunday?

Matchup Information – 49ers vs Bills

• Venue & Location: Highmark Stadium (Orchard Park, NY)
• Date: Sunday, December 1st, 2024
• Kick Off: 8:20pm Eastern
• Broadcast: NBC

Betting Odds

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Spread

• 49ers +6 (-110)
• Bills -6 (-110)

Money Line

• 49ers +245
• Bills -290

Total

• Over 44.5 (-110)
• Under 44.5 (-110)

Can 49ers End Losing Streak on the Road?

The 49ers travel to Buffalo and face the Bills on Sunday Night Football

Despite the probable return of Purdy, who Kyle Shanahan says he expects to play, things could be very rough for the 49ers. They are nursing serious injuries on both sides of the ball, and will be without several key players once again.

Offensive linemen Trent Williams and Aaron Banks, as well as Jordan Elliot and Nick Bosa on the defensive line are all out for this contest. LB Drew Greenlaw has still not returned for the 49ers either, and things are not looking bright. The 49ers are just 2-3 away from home this season, and like I mentioned, they are going to need to put points on the board.

Buffalo is 3rd in the NFL, scoring over 29 points per game. That number jumps to 35 points at home, and like I said, they’ve put up 30+ in five straight. The Bills are also Top 10 defensively in terms of scoring, giving up less than 20 per contest. I have very little faith in the 49ers to bounce back in this spot, as I don’t see anyone slowing down the Bills.

San Francisco’s once elite defense is 20th in points per game this season, allowing 29 per game the last two weeks. I think it’s the Bills in every way, shape, or form on Sunday Night, and I’ll do so by backing the offense.

San Francisco 49ers vs Buffalo Bills Best Bets

Back the Bills to continue rolling on offense this Sunday

San Francisco 49ers vs Buffalo Bills Prediction: Bills Win & Cover, No Lean on Total

Best Bet: Bills TT Over 26.5 (-105) Bovada

I’ll admit, this could be a trap. I’ll take the bait.

The Bills offense scores 29.1 points per game, and 35 at home. They’ve covered this number, scoring at least 27 points in 8/11 games this season, in 8 of their 9 wins, and in all 5 games at Highmark Stadium. Is that too easy of a though process? More than likely. But it’s enough for me to press this button.

Even if the field is snowy, the Bills rushing attack should get the job done. The 49ers are Top 10 in yards per rush allowed, but without some key D-Linemen, their tenacity will certainly take a hit. They allow over 320 yards per game, give up over 26 points on the road, and I don’t see them being able to slow down the way Allen has these Bills playing. Give me Buffalo to put some points on the board with minimal issues on Sunday Night.

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