Rams vs. 49ers Week 4 MNF Betting: Can the Rams Finally Beat Their NFC West Rivals?

Time has been flying by as we’re already approaching Week 4 of the 2022 NFL season. Another slate of exciting matchups is right around the corner, including a showdown between NFC West rivals as the Los Angeles Rams pay a visit to the San Francisco 49ers for Monday Night Football.

49ers beat Rams twice last season, once coming off an ugly loss to AZ, once playing 2 backup tackles.

That context obviously relevant now.

Garoppolo's avg time to throw was 2.3s (fastest in NFL) and 2.4s (#3), respectively. SF might need to quicken back up to that. 2.6s at DEN

— David Lombardi (@LombardiHimself) September 26, 2022

After a season-opening loss, the Rams have now won back-to-back games. Los Angeles’ last victory — a 20-12 win over the Arizona Cardinals — was a defensively dominant performance that saw Sean McVay’s squad hold its opponents to just four field goals made.

With Jimmy Garoppolo under center, the 49ers couldn’t get the job done against the Broncos, losing 11-10. It was an uneventful game that saw San Francisco score a touchdown in the first quarter, only to be held off the scoresheet until the final frame.

Betting News has gathered the latest Rams vs 49ers odds from BetOnline Sportsbook to help shed some light on the situation, along with a prediction and best bets for the NFL Week 4 game.

Los Angeles Rams vs San Francisco 49ers Week 4 Matchup Information and Betting Odds

Matchup Information

• Matchup: Los Angeles Rams (2-1, 1-0 Away) vs. San Francisco 49ers (1-2, 1-0 Home)
• Venue & Location: Levi's Stadium (Santa Clara, California)
• Date: Monday, Oct. 3, 2022
• Game Time: 8:15 p.m. Eastern Time
• Rams vs 49ers Info: ESPN, NFL+

Rams vs 49ers Odds

Game odds are via BetOnline as of Wednesday, Sept. 28 at 8:54 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.

Spread

• Los Angeles Rams +2.5 (-114)
• San Francisco 49ers -2.5 (-106)

Over/Under

• Over 42.5 (-108)
• Under 42.5 (-112)

Moneyline

• Los Angeles Rams +110
• San Francisco 49ers -130

Los Angeles Rams vs San Francisco 49ers Betting Trends

• The Rams are 6-0 straight up in their last six road games.
• San Francisco is 6-1 straight up in its last seven games against the Rams.
• The Rams are 4-1 against the spread (ATS) in their last five games played on Monday.
• San Francisco is 4-1 ATS in its last five games against the NFC West.
• The total has hit the under in seven of the Rams’ last nine road games against San Francisco.
• The total has hit the under in each of San Francisco’s last six games.

Los Angeles Rams vs San Francisco 49ers Prediction and Picks

Rams vs 49ers Prediction: Rams 23, 49ers 17

Rams vs 49ers Picks: Rams ML (Best Value: +110 at BetOnline) & Under 42.5 Points (Best Value: -112 at BetOnline)

Though the Rams beat the 49ers en route to Super Bowl LVI, Los Angeles hasn’t beaten its NFC West rival in the regular season since 2018. In fact, San Francisco has won six straight regular-season contests, meaning there’s a lot for the road team to prove.

The good news for the Rams is that there are things working in their favor. For starters, starting left tackle Trent Williams is out of the lineup with a high ankle sprain.

The 49ers pride themselves on their offensive line, but the unit won’t be nearly as strong without Williams. Considering how they allowed four sacks to the Broncos last week and the Rams already have seven on the season, it could be a busy day in the trenches.

There’s also the fact that Garoppolo didn’t look great filling in for the injured Trey Lance. While the veteran gunslinger went 18-of-29 for 211 passing yards and a TD, he did throw an interception and also lost a fumble.

In a lot of ways as crazy as it may seem, I think this is the biggest game of the year for the Rams. Haven't beaten the 49ers in San Fran since 2018. You finally broke the curse in the playoffs but have you cracked the code to continuously beat them. Biggest game of the year.

— JAKE ELLENBOGEN (@JKBOGEN) September 27, 2022

Of course, it won’t be easy for the Rams to produce offense against the 49ers. San Francisco’s defense allows only 12.3 points (No. 3) and 227.0 total offensive yards (No. 2) per game.

If the Rams are going to win, Matthew Stafford has to step up. The veteran QB hasn’t looked great this season, having more INTs (5) than he does TDs (4). He could be helped if his backfield finally wakes up after only averaging 72.3 rushing yards (No. 30) through three games.

Fortunately, Stafford will have Cooper Kupp to continue to lean on. Last season’s Offensive Player of the Year already leads the NFL with 28 receptions, turning them into 280 yards and three TDs. That’s not to mention his 20-yard rushing score from last week.

At the end of the day, the Rams have had their struggles with the 49ers, but I do trust Stafford and co. to get the win here. Garoppolo just didn’t look like himself last week and a battered offensive line will make it tougher for him to get his footing down.

I’m not expecting a high-scoring game either, hence why I’m taking the under on the total. Besides, seven of the last Rams-49ers games played at Levi’s Stadium have ended with the under being hit.

Both defenses will keep the game from getting out of hand, but the Rams’ slight edge on offense will be the reason why they head into Week 5 on a three-game winning streak.

More NFL Week 4 Stories on Betting News

• Dolphins vs Bengals Week 4 TNF Betting: Back Miami to Snag Upset Win in Cincinnati
• Vikings vs Saints Week 4 Betting: Can Winston Lead New Orleans to an Upset in London?
• Bills vs. Ravens Week 4 Betting: Who’ll Win the Jackson-Allen Showdown?
• Titans vs. Colts Week 4 Betting: Will Tennessee make it four straight wins in Indy?