Eagles vs. Cardinals Week 5 Betting: Back Philly to hand Arizona its 8th Straight Home Loss

Week 5 of the 2022 NFL season brings yet another slate of entertaining matchups. One showdown that’s catching many people’s eye is a battle between bird teams as the Philadelphia Eagles pay a visit to the Arizona Cardinals on Sunday.

The #Cardinals are debuting their alternate black jerseys and helmets against the Eagles on Sunday 👀🔥

📺: FOX 4:25pm ET | 📸: @AZCardinals pic.twitter.com/fCYbvK2iTi

— FOX Sports: NFL (@NFLonFOX) October 6, 2022

The Eagles are the NFL’s final remaining undefeated team, sitting at 4-0. Philadelphia extended its perfect start to the campaign following a 29-21 victory over the Jacksonville Jaguars last week that saw running back Miles Sanders turn 27 carries into 134 rushing yards and a pair of touchdowns.

There hasn’t been much consistency in the Cardinals’ early season, however, they do have momentum after beating the Carolina Panthers, 26-16, last week. Despite a slow start, Arizona battled back, led by quarterback Kyler Murray’s three-TD performance (two passing, one rushing).

Betting News has gathered the latest Eagles vs Cardinals odds from BetOnline Sportsbook to help shed some light on the situation, along with a prediction and best bets for the NFL Week 5 game.

Philadelphia Eagles vs Arizona Cardinals Week 5 Matchup Information and Betting Odds

Matchup Information

• Matchup: Philadelphia Eagles (4-0, 2-0 Away) vs. Arizona Cardinals (2-2, 0-2 Home)
• Venue & Location: State Farm Stadium (Glendale, Arizona)
• Date: Sunday, Oct. 9, 2022
• Game Time: 4:25 p.m. Eastern Time
• Eagles vs Cardinals Info: FOX

Eagles vs Cardinals Odds

Game odds are via BetOnline as of Friday, Oct. 7 at 8:47 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.

Spread

• Philadelphia Eagles -5.5 (-106)
• Arizona Cardinals +5.5 (-114)

Over/Under

• Over 48.5 Points (-115)
• Under 48.5 Points (-105)

Moneyline

• Philadelphia Eagles -240
• Arizona Cardinals +198

Philadelphia Eagles vs Arizona Cardinals Betting Trends

• Philadelphia is 8-2 straight up in its last 10 games.
• Arizona is 3-7 straight up in its last 10 games.
• Philadelphia is 0-5 against the spread (ATS) in its last five road games against Arizona.
• Arizona is 0-7 ATS in its last seven home games.
• The total has hit the under in five of Philadelphia’s last seven games against the NFC West.
• The total has hit the under in five of Arizona’s last seven games against Philadelphia.

Philadelphia Eagles vs Arizona Cardinals Prediction and Picks

Eagles vs Cardinals Prediction: Eagles 33, Cardinals 23

Eagles vs Cardinals Picks: Eagles -5.5 (Best Value: -106 at BetOnline) & Over 48.5 Points (Best Value: -115 at BetOnline)

This is a game that could get ugly if you’re a Cardinals fan. Arizona has been one of the more underwhelming teams to begin the 2022 season, highlighted by an abysmal defense that surrenders 25.8 points per game — the fifth-worst clip in the entire NFL.

On the flip side, the Eagles have the fourth-best offense in the league (28.8 PPG). Nick Siranni’s squad is more than good enough to beat teams both on the ground and through the air, which has played a big role in the undefeated start.

The Cardinals might be .500 at the moment, but their two wins came against underachieving teams — the Panthers and Las Vegas Raiders. Meanwhile, their two losses came against the Kansas City Chiefs and Los Angeles Rams by a combined score of 64-33, showing just how outclassed Arizona is by actually good teams.

Making matters worse, both of the Cardinals’ losses came at State Farm Stadium. In fact, they’ve lost seven straight games at home, having not won in their own barn since Week 7 of the 2021 NFL campaign.

In those seven losses, the Cardinals were outscored by their opponents by a total of 212-133. That translates to an average loss margin of nearly eight points per game.

With the Cardinals’ home struggles, I just don’t see how the Eagles lose to them on the road. Philadelphia might need to tighten up in some aspects, but they’re still good enough to extend their record to 5-0.

On top of an impressive offense, the Eagles own a top-10 scoring defense. That should be a major obstacle for a Cardinals team that’s scoring the fifth-fewest points (16.5 PPG) at home this season.

Outside of Marquise Brown, none of Arizona’s pass-catchers is much of a threat. Sure, tight end Zach Ertz will be motivated to do some damage against his former team, but the Eagles have given up the 10th-fewest receiving yards to his position this season.

Throw in the fact that Philly QB Jalen Hurts is clicking with his weapons and I could see the Eagles putting this to bed early. The Cardinals have been notorious for slow starts thus far, making it likely that they’ll be out of this game before they know it.

With how bad the Cardinals have been at home, I fully support the Eagles covering the 6.5-point spread. Furthermore, I can also see the total hitting over 48.5 points due to Philadelphia’s offense doing most of the heavy lifting.

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