Cardinals vs. Panthers Week 4 Betting: Can Arizona Beat Carolina for the First Time Since 2013?

Time has been flying by as we’re already approaching Week 4 of the 2022 NFL season. Another slate of exciting matchups is right around the corner, including an NFC meeting between the Arizona Cardinals and Carolina Panthers.

The Arizona Cardinals have not beaten the Carolina Panthers since October 6, 2013. Six games, four on the road. (includes playoffs).
Overall, the Panthers lead the series, 14-5.

Conversely, Kyler Murray is 2-0 vs Baker Mayfield.

— Chuck Harris (@chuckh3) September 26, 2022

The Cardinals’ campaign has not gone as expected. The team dropped to 1-2 after a 20-12 loss to the Los Angeles Rams over the weekend. Arizona’s offense just didn’t come to play as each of the Cardinals’ 12 points came from field goals.

Meanwhile, the Panthers ended their two-game losing streak with a 22-14 win against the New Orleans Saints in Week 3. Matt Rhule’s squad didn’t trail at any point of the game and even completely shut the Saints out in the first half.

Betting News has gathered the latest Cardinals vs Panthers odds from BetOnline Sportsbook to help shed some light on the situation, along with a prediction and best bets for the NFL Week 4 game.

Arizona Cardinals vs Carolina Panthers Week 4 Matchup Information and Betting Odds

Matchup Information

• Matchup: Arizona Cardinals (1-2, 1-0 Away) vs. Carolina Panthers (1-2, 1-1 Home)
• Venue & Location: Bank of America Stadium (Charlotte, North Carolina)
• Date: Sunday, Oct. 2, 2022
• Game Time: 4:05 p.m. Eastern Time
• Cardinals vs Panthers Info: FOX, NFL+

Cardinals vs Ravens Odds

Game odds are via BetOnline as of Thursday, Sept. 29 at 7:48 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.

Spread

• Thursday, September 29: Arizona Cardinals +1.5 (-110)/Carolina Panthers -1.5 (-110)
• Sunday, October 2: Arizona Cardinals -1 (-108)/Carolina Panthers +1 (-112)

Over/Under

• Thursday, September 29: Over 42.5 (-115)/Under 42.5 (-105)
• Sunday, October 2: Over 43.5 (-110)/Under 43.5 (-110)

Moneyline

• Thursday, September 29: Arizona Cardinals +100/Carolina Panthers -118
• Sunday, October 2: Arizona Cardinals -112/Carolina Panthers -104

Arizona Cardinals vs Carolina Panthers Betting Trends

• Arizona is 1-5 straight up in its last six games against the NFC.
• Carolina is 1-9 straight up in its last 10 games.
• Arizona is 0-6 against the spread (ATS) in its last six games against Carolina.
• Carolina is 1-7 ATS in its last eight home games.
• The total has hit the under in four of Arizona’s last six Week 4 matchups.
• The total has hit the over in five of Carolina’s last six games against Arizona.

Arizona Cardinals vs Carolina Panthers Prediction and Picks

Cardinals vs Panthers Prediction: Cardinals 23, Panthers 20

Cardinals vs Panthers Picks: Cardinals ML (Best Value: +100 at BetOnline) & Over 42.5 Points (Best Value: -115 at BetOnline)

The Cardinals and Panthers have squared off in 16 regular-season games since 1995. Carolina has emerged as the victor more often than not in the all-time series, winning 12 of those games.

If that wasn’t bad enough, the Cardinals haven’t beaten the Panthers in nearly a decade, losing each of the last four matchups.

Having said that, this upcoming Cardinals vs Panthers meeting could go either way. Neither team is looking amazing right now, showing signs of just how badly improvement is needed.

I do believe that the Cardinals will win this game, but they need Kyler Murray to step up if they hope for that to happen. The fourth-year quarterback is experiencing career-lows in both completion percentage (63.8%) and QB rating (82.6) while only throwing three touchdowns to one interception thus far.

Perhaps Arizona will finally give its run game a chance to shine. Arizona is only averaging 105.3 rushing yards per game (No. 17) and has yet to have a rusher surpass the 90-yard mark through three games.

The good news is that the Panthers allow 348.7 total yards per game (No. 18), so there should be plenty of opportunities for Murray to get things going. On the flip side, the Cardinals allow 383.7 yards (No. 23) per game, so the defense must come up with big stops as well.

Fortunately, the Panthers offense has struggled early on. The Baker Mayfield-led attack is averaging the third-fewest offensive yards this season, with the veteran QB not having the best chemistry with No. 1 wideout DJ Moore and running back Christian McCaffrey.

If the Cardinals defense can make crucial stops, the win should be theirs. It’s important to highlight that Arizona’s two losses this season came against the Rams and Kansas City Chiefs — two very good teams.

Meanwhile, the Panthers have lost to the New York Giants and Cleveland Browns. Maybe their win against the Saints was a sign of better things to come, however, New Orleans’ didn’t look that great and could’ve had an off-night on the road.

Nevertheless, I could see the Cardinals finding their grove here, which is why they’re playable at +100 on the moneyline. At the end of the day, Murray should outperform Mayfield, giving Arizona a solid chance at the W.

I’m also backing the over as rivalries tend to bring out the best in teams, plus there’s the fact that five of the last six Cardinals vs Panthers tilts have hit the over.

More Cardinals vs. Panthers Content on Betting News

• Cardinals vs. Panthers Consensus Picks, Score Projections & Betting Stats

More NFL Week 4 Stories on Betting News

• Vikings vs Saints Week 4 Betting: Can Winston Lead New Orleans to an Upset in London?
• Bills vs. Ravens Week 4 Betting: Who’ll Win the Jackson-Allen Showdown?
• Titans vs. Colts Week 4 Betting: Will Tennessee make it four straight wins in Indy?
• Rams vs. 49ers Week 4 MNF Betting: Can the Rams Finally Beat Their NFC West Rivals?
• Chiefs vs. Bucs Week 4 SNF Betting: Can Brady Win Back-to-Back Games Against Mahomes?