49ers vs. Rams | Week 3 Predictions & Best Bets

Divisional matchups are always just a little more exciting. The Rams and 49ers meet for the first time this year, coming to you live from SoFi Stadium in sunny Los Angeles.With so many injuries for both teams, we’ve got a lot to discuss; let’s jump right into it.

Here are our best bets for the 49ers vs Rams!

• • Brandon Aiyuk o72.5 Receiving Yards (-111) via BetOnline
  • Brock Purdy to throw 1+ Interception (+102) via BetOnline

49ers vs. Rams  Game Information

SoFi Stadium; Los Angeles, California

Matchup Information

• Location: SoFi Stadium; Los Angeles, California
• Date: Sunday, September 22nd, 2024
• Kickoff: 4:25 PM EST

Quarterback Matchup

• San Francisco 49ers: Jacoby Brissett (1-1; 2024 – 135 YPG | 1 TD | 0 INT)
• Los Angeles Rams: Aaron Rodgers (1-1; 2024 – 171.5 | 3 TD | 1 INT)

Betting Odds

Odds via BetOnline, an industry leader in the sports betting world.

Run Line

• San Francisco 49ers -6 (-106)
• Los Angeles Rams +6 (-114)

Money Line

• San Francisco 49ers (-300)
• Los Angeles Rams (+250)

Total

• Over 43 (-115)
• Under 43 (-105)

Get 50% up to $1,000 on your NFL picks today at BetOnline

49ers vs. Rams Analysis & Breakdown

Fred Warner records the sack on Matthew Stafford.

We’re just two weeks deep into the NFL season and the injury bug has run amok. Both the Rams and the 49ers are missing multiple players on both sides of the ball, and both teams are missing big names on the offense.

The Rams lost Puka Nacua in Week 1 and saw their other star wideout, Cooper Kup, go down in Week 2. 

The 49ers have been without their starting running back, Christian McCaffrey all season due to an inflamed hamstring, and now will be without Deebo Samuel for a few weeks due a calf injury.

It was just announced today that starting tight end for the 49ers, George Kittle, sat out practice on Thursday with a hamstring issue; his status for Sunday is now up in the air.

With such a big void left on both rosters, it’ll be interesting to see who steps up to fill in.

Brandon Aiyuk  o72.5 Receiving Yards (-111) via BetOnline – Get a $500 WELCOME BONUS 

Brandon Aiyuk hurdles a tackler on his way to a touchdown.

The 49ers offense has been absolutely decimated by injury and now with George Kittle also questionable for Sunday, it’s time to talk about who I think will see the biggest jump in volume; Mr. Brandon Aiyuk.

Last week, in a loss to the Minnesota Vikings, the Niners scored just 17 points and both Deebo/Kittle combined for 18 targets. Those 18 targets equated to 50% of Purdy’s pass attempts with 54% of his completions going to those same 2 guys.

Aiyuk missed all of training camp and the entirety of the pre-season due to contract negotiations with the 49ers. We’ve seen how much players in similar situations have struggled this year due to the lack of practice.

Less practice means fewer reps, fewer reps is what lead’s to the timing issues and a lack of connection between a quarterback and his receivers. It’s also why both Kittle and Samuel have seen 32 combined targets through two weeks; they were present at training camp.

We saw this on full display in Weeks 1 and 2; Aiyuk saw 5 targets but caught just 2 passes for 28 yards, even dropping an easy touchdown. In Week 2 Aiyuk followed it up by catching 4 of his 5 targets for 43 yards in a loss to the Vikings.

Now with no Deebo, no McCaffrey and potentially no Kittle; it’s time for Aiyuk to step up take charge.

Brandon Aiyuk o72.5 Receiving Yards (-111) via BetOnline

Bonus Bet: Brandon Aiyuk 100+ Receiving Yards (+260)

Get 50% up to $1,000 on your NFL picks today at BetOnline

Brock Purdy to throw 1+ Interception (+102) via BetOnline – Get a $500 WELCOME BONUS 

With so many offensive pieces missing for Purdy, I get the feeling we could see some tipped balls, and maybe even some timing issues between Purdy and the next guys up. I know that Kittle’s status is still questionable, but even if he plays I like this prop.

Purdy started 16 games last year, threw 31 touchdowns and just 11 interceptions. He failed to record an interception against Los Angeles last year, but this year it’s a very different situation. The Niners enter this game on the road, against a Rams team that is desperate not to go 0-2.

Purdy will be without McCaffrey and without Deebo Samuel this week; two of his biggest weapons on this offense. In a divisional game, on the road, and against a team hungry for their first win of the year. Look for the defense to step up and get us the 1 interception we need.

30% off all Betalytics Packages, Code: BNEWS

Brock Purdy to throw 1+ Interception (+102) via BetOnline

Get 50% up to $1,000 on your NFL picks today at BetOnline

To Recap, NFL Bets for September 22nd, 2024:

In the 49ers vs. Rams game on Sunday, we’re rolling with 2 plays. Brandon Aiyuk o72.5 Receiving Yards (-111), and Brock Purdy to throw 1+ Interception (+102); both via BetOnline.

Follow me on ‘X’ @VSaaauce for all my picks and sports takes you didn’t ask for!

Follow Betting News on ‘X’ and Twitch and catch us on stream!

Betting News on TikTok! Follow us for more picks, and news!

In need of a sportsbook? Check out one of our favorites below and sign-up for a bonus!

Still Here?

More Betting Stories

• 2024 World Series Prediction & Odds
• 2024 MLB Home Run Leader Predictions & Odds
• 2024 AL/NL MVP Predictions & Picks
• 2024 AL/NL Cy Young Predictions & Picks

v