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49ers vs Browns Prediction, Odds & Picks — Week 6: San Francisco Overcomes Rainy Conditions
Written by: Devon Platana
Last Updated:
Read Time: 6 minutes
nfl
San Francisco 49ers Odds
Spread
Total
Moneyline
-6.5
-111
33
-111o
-454
Cleveland Browns Odds
Spread
Total
Moneyline
+6.5
-117
33
-117u
+335
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See Picks & Statistics For The GameThe NFL Week 6 schedule is loaded with 15 matchups, bringing a plethora of betting opportunities to the table. One matchup that football fanatics are looking forward to is Sunday’s 1 p.m. ET showdown between the undefeated San Francisco 49ers and injury-plagued Cleveland Browns.
The 49ers improved to 5-0 on the 2023 campaign with Sunday night’s huge 42-10 win over the Dallas Cowboys. Meanwhile, the Browns are coming off their bye week and hope to find better results after falling 28-3 to the Baltimore Ravens in Week 4.
Can San Francisco continue to flirt with perfection? Or will Cleveland do the improbable by upsetting the Super Bowl favorites?
This 49ers vs. Browns preview covers everything you need to know before Sunday’s clash, including the latest NFL odds, matchup predictions, and the best bets you can make.
49ers vs Browns Preview — NFL Week 6
49ers vs Browns Game Information
- Matchup: San Francisco 49ers (5-0, 2-0 Away) vs. Cleveland Browns (2-2, 2-1 Home)
- Venue & Location: Cleveland Browns Stadium (Cleveland, OH)
- Date: Sunday, Oct. 15, 2023
- Game Time: 1 p.m. Eastern Time
- 49ers vs. Browns TV Channel: FOX
49ers vs Browns Odds
NFL game odds courtesy of BetOnline as of Saturday, Oct. 14 at 7:16 p.m. ET. Odds from other sportsbooks may also be mentioned in this article.
Spread
- San Francisco 49ers -10 (-105)
- Cleveland Browns +10 (-115)
Over/Under
- Over 36 Points (-115)
- Under 36 Points (-105)
Moneyline
- San Francisco 49ers -505
- Cleveland Browns +400
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Now, back to the gridiron…
49ers vs Browns Betting Trends
- San Francisco is 6-1 straight up in its last seven road games.
- Cleveland is 1-6 straight up in its last seven games played in October.
- San Francisco is 4-1 ATS in its last five Week 6 matchups.
- Cleveland is 0-6 ATS in its last six games against the NFC West.
- The total has hit the Over in five of San Francisco’s last six games played in October.
- The total has hit the Under in each of Cleveland’s last five games against San Francisco.
49ers vs Browns Prediction — NFL Week 6
Even though the Browns are feeling well-rested after their bye, a few things are working against them this week.
For starters, quarterback Deshaun Watson’s health is still up in the air. The veteran gunslinger is dealing with a shoulder injury and there’s no telling if he’ll be good to go for Sunday. If he can’t play, it’s expected that third-string QB P.J. Walker will start in his place.
Update: Deshaun Watson has officially been ruled out, per ESPN.
Cleveland was forced to start rookie QB Dorian Thompson-Robinson in Watson’s place back in Week 4. The result was a disaster as DTR went 19-of-36 (52.8%) in the pocket for 121 passing yards with three interceptions.
Truthfully, it doesn’t matter who starts against San Francisco’s elite defense. The 49ers are only allowing 13.6 points per game (No. 1) and 4.4 yards per play (No. 3) while only allowing more than 16 points once through five games.
Furthermore, the 49ers are tied for the most interceptions (8) and have racked up the fifth-most INT yards (118), proving that they can make the Browns pay for their mistakes.
Credit should be given where it’s due and it isn’t like the Browns are slouches on defense, either. Cleveland allows an NFL-low 3.8 yards per play while only allowing 15.0 PPG (T-No. 2).
Kevin Stefanski’s team also applies pressure on 30.3% of dropbacks, meaning the San Francisco offensive line needs to do everything in its power to protect QB Brock Purdy.
But even with a ton of talent across the board, the Browns’ defense has yet to face a team as dangerous as the 49ers. San Francisco can do damage in multiple ways, aided by an embarrassment of offensive talent in the form of names like Christian McCaffrey, Brandon Aiyuk, and more.
Sunday’s forecast is also shaping up to be rainy and cold, meaning both sides could be forced to run the ball more. If that’s the case, I give San Francisco the edge. The Niners generate the third-most rushing yards in the league, whereas the Browns went from averaging 202 rushing yards in games where Nick Chubb played to 85.5 without him.
At the end of the day, the 49ers outclass the Browns across the board and shouldn’t have an issue leaving Cleveland with a victory, even if weather winds up playing a factor.
Prediction: 49ers 27, Browns 16
Bet: 49ers -10 (-105 on BetOnline)
49ers vs Browns Player Prop — Week 6
Although 49ers vs. Browns player prop odds aren’t available yet, let’s look ahead by projecting a George Kittle anytime touchdown.
Kittle was absolutely electric against the Cowboys, hauling in three passes for 67 yards and his first three TDs of the season. He’s in a good spot to score again because even though the Browns have allowed the fewest receptions to tight ends, they’ve still allowed two TDs to the position.
With poor weather likely forcing Purdy to make more quick and short passes, expect Kittle to see enough volume to score.
Bet: George Kittle Anytime Touchdown (+220 on BetOnline)
49ers vs Browns Week 6 FAQ
When is 49ers vs Browns?
- The 49ers and Browns will collide on Sunday, Oct. 15, 2023.
Where is 49ers vs Browns?
- The 49ers and Browns will play each other at Cleveland Browns Stadium in Cleveland, Ohio.
What time does 49ers vs Browns start?
- Kickoff for the upcoming SF vs. CLE matchup is slated for 1 p.m. ET.
How can I watch 49ers vs Browns?
- 49ers and Browns fans can tune in to FOX for Sunday’s matchup.
How can I bet on 49ers vs Browns?
- All of the top online sports betting sites will have NFL odds, but here are some of the sites we recommend most for football enthusiasts.
Devon is a Master of Journalism graduate who joined the sports betting world in 2020. His favorite leagues to cover are the NHL, NBA and NFL, and has a soft spot for fantasy football specifically. Outside of sports, he enjoys the finer things in life like pasta, live music and getting even more tattoos.
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